Primary gastric conduit cancer (GCC) is a known but rare occurrence post-esophagectomy with gastric reconstruction of the esophagus. As improvements in post-esophagectomy treatment and surveillance have increased patient survival, GCC is becoming more common, with a reported incidence of 0.2-3.5%. We present the case of a 76-year-old man with metachronous adenocarcinoma of the gastric conduit antrum 10 years after Ivor-Lewis esophagectomy for esophageal adenocarcinoma. He was treated by a total gastrectomy with colonic interposition for esophageal reconstruction.
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